The information on this website is not intended for diagnosis or treatment. Please consult your physician for health concerns.

+90 850 321 50 00

Intradetrusor Botulinum Toxin Injection

Botulinum toxin injection into the bladder muscle for overactive bladder.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Üroloji department. Book Appointment →

What is Intradetrusor Botulinum Toxin Injection?

Intradetrusor botulinum toxin (onabotulinumtoxinA) injection involves cystoscopic injection of toxin into 20-30 sites of the bladder muscle (detrusor) using a fine needle to reduce overactive bladder contractions.

Standard dose is 100 U for idiopathic overactive bladder (OAB) and 200 U onabotulinumtoxinA for neurogenic detrusor overactivity (multiple sclerosis, spinal cord injury).

Effect begins within 2-4 weeks and lasts an average of 6-9 months. Repeat injections can be performed when efficacy diminishes. It is a second-line treatment for patients who do not respond to oral antimuscarinic therapy.

Symptoms

Refractory overactive bladder (OAB)
Urge incontinence (unresponsive to antimuscarinics)
Neurogenic detrusor overactivity (MS, spinal cord)
Interstitial cystitis/painful bladder syndrome
Idiopathic detrusor overactivity

Risk Factors

Urinary retention (5-10% in OAB, 30-40% in neurogenic bladder)
Urinary tract infection
Transient hematuria
Need for clean intermittent catheterization (CIC)
Diminished efficacy over time (very rare)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If urinary incontinence persists despite medical therapy
  • If inability to urinate develops after injection (retention)
  • If fever or dysuria occurs after injection
  • When efficacy duration ends, for repeat injection planning

Treatment Methods

01
Cystoscopic intradetrusor injection (100-200 U onabotulinumtoxinA)
02
Trigone-sparing injection at 20-30 sites
03
Office or day-case application under local anesthesia
04
Repeat injections (every 6-12 months as needed)
05
CIC training (in patients with retention risk)

Which Department to Visit?

You can visit our Üroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Üroloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

Book AppointmentContact Us

Related Health Topics

Other articles from the same department you may want to explore.

ESWL (Extracorporeal Shock Wave Lithotripsy)

Üroloji

ESWL delivers focused extracorporeal shock waves to fragment kidney stones into small pieces that can pass through the urinary tract spontaneously.

TURP (Transurethral Resection of the Prostate)

Üroloji

TURP is the endoscopic resection of prostatic adenoma causing lower urinary tract obstruction in benign prostatic hyperplasia.

Cystoscopy (Bladder Endoscopy)

Üroloji

Cystoscopy passes a thin endoscope through the urethra to inspect the bladder and urethra directly for both diagnostic and therapeutic purposes.

Varicocelectomy (Varicocele Surgery)

Üroloji

Varicocelectomy is a microsurgical or laparoscopic ligation of the enlarged veins of the pampiniform plexus; it plays an important role in treating male infertility.

Nephrectomy (Kidney Cancer Surgery)

Üroloji

Nephrectomy is the surgical procedure to remove a kidney with cancer (renal cell carcinoma) either radically or partially.

Radical Prostatectomy

Üroloji

Radical prostatectomy is the surgical removal of the entire prostate and seminal vesicles in localised prostate cancer; the robotic approach is today's standard.

Urethroplasty (Urethral Stricture Surgery)

Üroloji

Urethroplasty is the surgical widening or reconstruction of a urethral stricture; success rates are 85-95%.

Radical Orchiectomy (Testicular Cancer)

Üroloji

Radical inguinal orchiectomy is the surgery to remove the cancer-bearing testis along with the spermatic cord through a groin incision, used both for diagnosis and treatment of testicular cancer.

Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.