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Uterine Transplantation

In absolute uterine factor infertility, uterus transplantation from a living or deceased donor is offered.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Uterine Transplantation?

Uterine transplantation is a complex transplant surgery in which a uterus from a living or deceased donor is implanted into a recipient with absolute uterine factor infertility. It is performed in a limited number of centers worldwide, and protocol standardization is ongoing.

The process includes donor selection, resection, vascular anastomosis, immunosuppressive therapy, and embryo transfer. Pregnancy is usually started 6-12 months after transplantation, and deliveries are by cesarean. The graft is usually removed (hysterectomy) after one or two live births.

Ethical debates, fetal effects of long-term immunosuppression, and high cost are reasons the procedure has limited application. Teams closely monitor cardiovascular, infectious, and nephrotoxic side effects.

Symptoms

Primary amenorrhea (MRKH syndrome)
Congenital absence of uterus
Hysterectomy following uterine cancer
History of obstetric hysterectomy
Recurrent implantation failure
Following uterine rupture

Risk Factors

MRKH syndrome
Uterine agenesis
Severe Asherman syndrome
History of peripartum hysterectomy
Recovery after uterine sarcoma
Severe congenital uterine anomalies

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When diagnosed with primary amenorrhea and uterine absence
  • For fertility counseling after cancer
  • When program eligibility evaluation is requested
  • When ethical and psychosocial evaluation is required

Treatment Methods

01
Donor evaluation and immune compatibility tests
02
Transplantation surgery and vascular anastomosis
03
Immunosuppressive therapy (tacrolimus, azathioprine, steroids)
04
Embryo transfer with IVF
05
High-risk pregnancy follow-up
06
Planned cesarean delivery and postpartum hysterectomy

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.