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Sentinel Lymph Node Biopsy in Gynecologic Oncology

A lymph-node mapping technique that reduces morbidity in endometrial and vulvar cancer.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Sentinel Lymph Node Biopsy in Gynecologic Oncology?

Sentinel lymph node (SLN) mapping identifies the first lymph node receiving lymphatic drainage from the tumor. Indocyanine green (ICG), methylene blue, or technetium-99m radiocolloid can be used.

In endometrial cancer, near-infrared camera-guided SLN detection with cervical injection has become standard. The FIRES and SENTI-ENDO trials demonstrate the reliability of the technique.

In vulvar cancer, SLN can be used in early-stage (T1b <4 cm) patients as an alternative to full inguinofemoral lymphadenectomy. Research is also ongoing in cervical cancer.

Symptoms

Early-stage endometrial cancer
Early-stage cervical cancer (selected)
Unifocal vulvar cancer <4 cm
Lateralized vulvar lesion
Clinically lymph-node-negative cancer
Desire to avoid complete lymphadenectomy

Risk Factors

Deep myometrial invasion
Lymphovascular invasion
High-grade histology
Mid/deep cytological localization
Tumor size
Long-term chronic lymphedema risk

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • After diagnosis of endometrial cancer, during staging surgery
  • In the management of early-stage vulvar cancer
  • In suitable candidates with cervical cancer
  • In patients concerned about chronic lymphedema

Treatment Methods

01
Lymph node mapping with ICG or Tc-99m
02
Near-infrared camera-guided SLN biopsy
03
Search for micrometastasis with ultra-staging pathology
04
Decision on additional risk-based lymphadenectomy
05
Adjuvant therapy planning
06
Long-term lymphedema follow-up

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.