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Phaeochromocytoma Crisis

Hypertensive emergency due to massive catecholamine release.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Acil Servis department. Book Appointment →

What is Phaeochromocytoma Crisis?

Phaeochromocytoma is a chromaffin-cell tumour arising from the adrenal medulla or extra-adrenal sympathetic ganglia; in 10-15% of cases it is malignant and 30-40% is associated with familial syndromes.

Crisis presents with severe hypertension, headache, palpitations, sweating, abdominal pain, anxiety, hyperglycaemia, end-organ damage and life-threatening complications.

Diagnosis requires plasma free metanephrines, 24-hour urine catecholamines, abdominal CT/MRI and 123-I MIBG scintigraphy. Definitive treatment is preoperative alpha-blockade followed by laparoscopic adrenalectomy.

Symptoms

Severe headache
Palpitations
Sweating
Hypertensive attack
Abdominal pain
Anxiety
Tremor

Risk Factors

Family history
Multiple endocrine neoplasia syndrome
Von Hippel-Lindau disease
Neurofibromatosis type 1
Adrenal mass
Resistant hypertension
Anxiety disorder

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Sudden severe hypertension
  • Severe headache and palpitations
  • Severe sweating
  • Sudden chest pain
  • Loss of consciousness

Treatment Methods

01
Phenoxybenzamine alpha-blockade
02
Beta-blockade after adequate alpha-blockade
03
Calcium-channel blockers
04
Volume expansion
05
Metyrosine in selected cases
06
Definitive surgery: laparoscopic adrenalectomy

Which Department to Visit?

You can visit our Acil Servis department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Acil Servis Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.