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Ovulation Induction

Stimulation of ovulation with medication is the first-line treatment for ovulatory infertility.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Ovulation Induction?

Ovulation induction aims to provide regular follicular development and ovulation by stimulating the hypothalamic-pituitary-ovarian axis. It is the primary treatment for chronic anovulation such as PCOS, and is also used in IUI and IVF cycles.

Clomiphene citrate and letrozole are oral agents and are first-line options for inducing ovulation in PCOS. Letrozole has surpassed clomiphene in pregnancy rates in PCOS and has become the first choice in guidelines.

Gonadotropins (FSH, hMG) are administered by injection and are preferred in cases unresponsive to oral agents. Multiple pregnancy and ovarian hyperstimulation syndrome (OHSS) risks are managed with careful ultrasonographic follow-up and hormone measurements.

Symptoms

Chronic anovulation or oligo-ovulation
Irregular or long-interval menstrual periods
Inability to track LH surge with basal body temperature
Insufficient follicular development on ultrasonography
Persistently negative urinary ovulation tests
Anovulation due to PCOS, hyperprolactinemia, or hypothyroidism

Risk Factors

PCOS
Hyperprolactinemia
Thyroid disorders
Obesity
Stress or excessive exercise
Low ovarian reserve (decreased response to OI)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • For infertility evaluation due to irregular menstruation
  • When pregnancy is planned after PCOS diagnosis
  • When no response is obtained after 3-6 cycles of oral agent therapy
  • Urgent if OHSS symptoms (abdominal distension, pain, dyspnea) begin

Treatment Methods

01
Letrozole 2.5-7.5 mg/day, cycle days 3-7 (first-line in PCOS)
02
Clomiphene citrate 50-150 mg/day, cycle days 3-7
03
Metformin: adjuvant therapy for insulin resistance in PCOS
04
Gonadotropins: low-dose FSH protocols in oral agent unresponsiveness
05
Ovulation triggering with hCG: when follicle is ≥18 mm
06
Ovarian stimulation monitoring with follicular ultrasonography

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.