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Orthopedic Biologic Therapies

PRP, BMAC, MSC and orthobiologic interventions for joint, tendon and cartilage disorders

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Ortopedi ve Travmatoloji department. Book Appointment →

What is Orthopedic Biologic Therapies?

PRP delivers concentrated platelets and growth factors (PDGF, TGF-β, VEGF, IGF-1) to modulate inflammation, recruit progenitors and support tissue repair, with leukocyte-poor preparations preferred for OA and leukocyte-rich for tendinopathy.

BMAC and adipose-derived MSC therapies combine progenitor cells, cytokines and extracellular matrix factors to enhance regeneration in cartilage defects, focal OA and rotator-cuff augmentation.

Scaffold-based and orthobiologic surgery includes osteochondral allograft, MACI (matrix-induced chondrocyte implantation), nano-hydroxyapatite scaffolds and amniotic membrane allografts to support biologic repair of cartilage and tendon.

Symptoms

Knee osteoarthritis with persistent pain
Chronic tendinopathy (lateral epicondyle, Achilles, patellar)
Focal cartilage defects on MRI
Partial rotator-cuff tears not requiring repair
Refractory plantar fasciitis

Risk Factors

Active malignancy or hematologic disorder
Active infection at injection site
Severe coagulopathy
Pregnancy
Unrealistic patient expectations

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Persistent joint pain despite first-line therapy
  • Tendinopathy not responding to physiotherapy
  • Discussion of cartilage-restoration options
  • Pre-surgical augmentation planning
  • Worsening function despite injections

Treatment Methods

01
Diagnostic imaging (X-ray, MRI, ultrasound) to confirm pathology
02
Ultrasound-guided PRP injection for OA or tendinopathy
03
BMAC or MSC therapy in selected cases
04
Combine biologics with structured rehabilitation
05
Scaffold-based cartilage surgery for focal defects
06
Long-term outcome monitoring with PROMs (KOOS, IKDC)

Which Department to Visit?

You can visit our Ortopedi ve Travmatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Ortopedi ve Travmatoloji Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.