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Nuchal Translucency (NT) at 11–14 Weeks

Nuchal thickness measurement is the cornerstone of Down syndrome screening.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Nuchal Translucency (NT) at 11–14 Weeks?

Nuchal translucency is the measurement of normal subcutaneous fluid thickness between the skin and soft tissue in the fetal cervical region. It must be performed between 11–14 weeks (CRL 45–84 mm), a period in which the fetal lymphatic system is still developing.

If NT is above 3.5 mm, further investigation for chromosomal anomalies (Down, Edwards, Patau), cardiac defects, skeletal dysplasias and genetic syndromes is required. Even in cases of increased NT with a normal karyotype, fetal echocardiography is recommended.

NT is not used alone; combined with maternal age, PAPP-A and free beta-hCG (combined/dual test), the detection rate for Down syndrome reaches 85–90%.

Symptoms

NT ≥3.5 mm: considered high risk
Findings of hydrops fetalis: generalized subcutaneous edema
Cystic hygroma: prominent septated cystic mass behind the neck
Absent nasal bone (additional marker)
Reversed A-wave in ductus venosus
Tricuspid regurgitation

Risk Factors

Advanced maternal age
History of previous pregnancy with anomaly
Family history of chromosomal anomaly
Inherited syndromes
Family history of cardiac disease
Consanguineous marriage

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • For first-trimester screening between weeks 11–14
  • To a perinatology unit when NT is found high
  • For urgent genetic counseling if cystic hygroma is detected
  • When the dual test result is high risk
  • When fetal echocardiography is required

Treatment Methods

01
Standardized NT measurement performed by a certified physician
02
Dual test: combined risk calculation with PAPP-A and free beta-hCG
03
High risk: NIPT or chorionic villus sampling (CVS)
04
Fetal echocardiography (around week 20)
05
Genetic counseling
06
Follow-up ultrasound for anomaly screening

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.