Liver Diseases in Pregnancy

Management of pregnancy-specific and concurrent liver pathologies.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Liver Diseases in Pregnancy?

Pregnancy-specific liver diseases are classified by trimester: hyperemesis gravidarum (1st trimester), intrahepatic cholestasis (2nd-3rd trimester), preeclampsia/HELLP syndrome and acute fatty liver of pregnancy (3rd trimester).

Acute fatty liver of pregnancy (AFLP) is rare but life-threatening; fulminant hepatic failure may develop. Definitive treatment is delivery. Perinatal transmission prevention strategies are important in pregnant carriers of chronic hepatitis B/C.

Symptoms

Jaundice

Severe abdominal pain (right upper quadrant)

Nausea and vomiting

Pruritus (in cholestasis)

Coagulopathy findings

Hepatic encephalopathy (in AFLP)

Risk Factors

History of cholestasis in previous pregnancy

Multiple pregnancy (AFLP risk)

Preeclampsia history

LCHAD mutation carrier

Chronic hepatitis B/C

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

New-onset jaundice in pregnancy
Severe pruritus (especially palms and soles)
Abdominal pain and elevated liver enzymes
Coagulopathy findings (easy bruising, bleeding)

Treatment Methods

Cholestasis: ursodeoxycholic acid (UDCA)

HELLP: magnesium sulfate and delivery planning

AFLP: emergent delivery and intensive care support

Correction of coagulopathy (FFP, cryoprecipitate)

Chronic hepatitis B: tenofovir in 3rd trimester

Postpartum liver function follow-up

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.