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Management of the Poor Responder in IVF

Individualized stimulation plans are applied to poor responders according to the Bologna and POSEIDON criteria.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Management of the Poor Responder in IVF?

Poor response in IVF is a clinical problem associated with insufficient oocyte retrieval and low cumulative live birth rates. The POSEIDON classification considers age, ovarian reserve markers, and the response to previous cycles.

Treatment strategies include microflare, antagonist protocol, luteal phase stimulation (dual stim), high-dose gonadotropin, LH support (HMG), androgen and DHEA priming, coenzyme Q10, and growth hormone support.

Specialized laboratory practices try to improve success rates with IVM (in vitro maturation), rescue ICSI, euploid embryo selection by PGT-A, and cumulative embryo banking.

Symptoms

Low AMH level
Low antral follicle count
Fewer than 4 oocytes in previous cycles
Advanced maternal age
History of long-term failed IVF
Reduced serum estradiol response

Risk Factors

Advanced maternal age
Ovarian surgery (endometrioma, oophorectomy)
History of chemotherapy or radiotherapy
Turner mosaicism or FMR1 premutation
Smoking
Autoimmune oophoritis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When low AMH is detected
  • After failed IVF cycles
  • When menopausal symptoms begin
  • When the window for fertility preservation narrows

Treatment Methods

01
POSEIDON-based protocol selection
02
Luteal phase or dual stimulation
03
Androgen and DHEA priming
04
High-dose gonadotropin and LH activity
05
Cumulative embryo banking
06
Euploid embryo transfer with PGT-A

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.