Ewing Sarcoma

Aggressive primary bone tumor of childhood and adolescence.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 9, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Ortopedi ve Travmatoloji department. Book Appointment →

What is Ewing Sarcoma?

Ewing sarcoma is a highly malignant bone tumor of the small round blue cell tumor family, generally seen between the ages of 10 and 20. The EWS-FLI1 fusion gene translocation is characteristic.

It most commonly arises in the diaphysis of the femur, pelvis, tibia, and humerus; the soft tissue component is often large. The tumor grows rapidly and metastasizes to the lungs early.

Treatment requires a multidisciplinary approach; with combined surgery, chemotherapy, and radiotherapy, the 5-year survival rate in localized disease may reach 60-70%.

Symptoms

Progressive bone pain

Local swelling and mass

Fever and night sweats

Weight loss and fatigue

Pathologic fracture

Lymphadenopathy

Tiredness and pallor

Risk Factors

Age range 10-20

Male sex (slight predominance)

White race

EWSR1 gene translocation

Prior radiotherapy

Congenital anomalies

Family history of cancer

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

When a child has persistent bone pain
When local swelling is enlarging
When systemic symptoms (fever, weight loss) are present
When a pathologic fracture has occurred
When limping persists

Treatment Methods

Neoadjuvant chemotherapy

Wide surgical resection

Radiotherapy

Adjuvant chemotherapy (VAC/IE protocols)

Reconstructive surgery (endoprosthesis, allograft)

Pediatric oncology follow-up

Which Department to Visit?

You can visit our Ortopedi ve Travmatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Ortopedi ve Travmatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.