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Endometrial Hyperplasia

Abnormal thickening of the inner lining of the uterus.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Endometrial Hyperplasia?

Endometrial hyperplasia is the thickening of the uterine inner lining beyond normal. Estrogen exposure unopposed by progesterone is the most important cause. It is divided into atypical and non-atypical forms.

Non-atypical hyperplasia carries a low malignancy risk (1-3%), while atypical endometrial hyperplasia carries a 30-40% risk of progression to endometrial cancer. Therefore more aggressive treatment is required for atypical forms.

Abnormal uterine bleeding is the most common symptom. Diagnosis is made by endometrial thickness measurement on transvaginal ultrasound and endometrial biopsy. Hysteroscopy-guided biopsy increases diagnostic accuracy.

Symptoms

Irregular or excessive menstrual bleeding
Bleeding between two periods
Postmenopausal bleeding
Prolonged menstrual periods
Pelvic pain (rare)

Risk Factors

Obesity (peripheral estrogen conversion)
Anovulation and PCOS
Tamoxifen use
Nulliparity
Late menopause
Estrogen-containing hormone replacement therapy

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When there is menstrual irregularity or abnormal bleeding
  • When postmenopausal bleeding is seen
  • When thickened endometrium is detected on ultrasonography

Treatment Methods

01
Progesterone therapy (in non-atypical hyperplasia)
02
Levonorgestrel-releasing IUD (Mirena)
03
Hysterectomy (in atypical hyperplasia or treatment-resistant cases)
04
Weight management and lifestyle changes
05
Follow-up with regular endometrial biopsy

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.