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Congenital Hypothyroidism Follow-up in Children

Newborn-onset thyroid hormone deficiency and lifelong follow-up.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Çocuk Sağlığı ve Hastalıkları department. Book Appointment →

What is Congenital Hypothyroidism Follow-up in Children?

Congenital hypothyroidism (CH) is a thyroid hormone deficiency present at birth, affecting approximately 1 in 2000–4000 live births. Thyroid dysgenesis (75–80%) is most common, followed by dyshormonogenesis (15–20%).

It is detected by routine newborn screening (TSH and/or T4 measurement on the heel-prick test). After confirmation by diagnostic tests (serum TSH, free T4, thyroid scintigraphy/ultrasound), levothyroxine treatment is started promptly.

Levothyroxine 10–15 µg/kg/day is the initial dose, started within the first 2 weeks of life. The goal is to keep TSH 0.5–2 mIU/L and free T4 in the upper half of the normal range. Follow-up includes growth, neurological development and bone age assessment.

Symptoms

Asymptomatic in newborn period (with screening)
Prolonged jaundice
Macroglossia
Umbilical hernia
Hypotonia
Hypothermia
Constipation

Risk Factors

Thyroid dysgenesis (most common)
Dyshormonogenesis
Maternal thyroid disease
Antithyroid drug use
Iodine deficiency/excess
Down syndrome

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Positive newborn screening result
  • Prolonged jaundice
  • Macroglossia and umbilical hernia
  • Hypotonia and feeding problems
  • Family history of thyroid disease
  • Postnatal growth retardation

Treatment Methods

01
Levothyroxine (10–15 µg/kg/day)
02
Treatment within the first 2 weeks
03
Regular TSH/T4 monitoring
04
Growth and neurodevelopment follow-up
05
Bone age assessment
06
Lifelong endocrine follow-up

Which Department to Visit?

You can visit our Çocuk Sağlığı ve Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Çocuk Sağlığı ve Hastalıkları Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.