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Chorionic Villus Sampling (CVS)

An invasive prenatal diagnostic method that can be performed in the first trimester.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Kadın Hastalıkları ve Doğum department. Book Appointment →

What is Chorionic Villus Sampling (CVS)?

CVS is the collection of a sample from the fetal-derived part of the placenta (chorionic villus) under ultrasound guidance via the transcervical or transabdominal route. It is performed between weeks 10-13 and provides early prenatal diagnosis.

Since chorionic villus cells obtained are of fetal origin, they are suitable for chromosomal analysis and molecular tests. Results are obtained more quickly than with amniocentesis (direct preparation in 48 hours).

The risk of pregnancy loss with CVS is approximately 0.2-0.5%; in experienced centers, it is considered to be of similar safety to amniocentesis. As it does not allow for neural tube defect screening, second-trimester AFP follow-up is necessary.

Symptoms

High-risk pregnancies requiring early diagnosis
Family history of inherited genetic disease
Advanced maternal age
Increased NT on ultrasound
Previous pregnancy with anomaly
Carrier parents (thalassemia, SMA, etc.)

Risk Factors

Risk of pregnancy loss (0.2-0.5%)
Vaginal bleeding
Intrauterine infection
Placental mosaicism (1-2%)
Rh isoimmunization
Risk of limb defect if performed before week 10

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Between weeks 10-13 for early diagnosis
  • When NT is found high
  • When NIPT is high-risk
  • For specific genetic disease in known family history
  • When early result is desired in advanced age pregnancy

Treatment Methods

01
Ultrasound-guided transabdominal or transcervical sampling
02
Direct chromosome analysis (48 hours)
03
Long-term culture (7-14 days)
04
Specific genetic tests (thalassemia, SMA, cystic fibrosis)
05
Amniocentesis confirmation in case of mosaicism
06
Anti-D administration in Rh-negative pregnant women

Which Department to Visit?

You can visit our Kadın Hastalıkları ve Doğum department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Kadın Hastalıkları ve Doğum Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.