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Platelet-Rich Plasma (PRP) Injection for Joint Disorders

Autologous platelet concentrate injection for osteoarthritis and selected tendon and ligament conditions.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Fizik Tedavi ve Rehabilitasyon department. Book Appointment →

What is Platelet-Rich Plasma (PRP) Injection for Joint Disorders?

PRP is prepared by centrifuging a small volume of the patient's blood to concentrate platelets and their growth factors (PDGF, TGF-β, VEGF). The concentrate is injected into the joint or peritendinous tissue.

Common indications include knee osteoarthritis (especially Kellgren-Lawrence grade I–III), epicondylitis, plantar fasciitis, rotator cuff tendinopathy and selected ligament injuries; evidence is strongest for early-stage knee osteoarthritis.

Treatment is delivered by image-guided injection in 1–3 sessions over weeks. Outcomes vary with patient age, BMI, joint severity, leukocyte content of the preparation and exercise rehabilitation after the procedure.

Symptoms

Persistent joint pain despite physiotherapy
Mild-to-moderate osteoarthritis
Chronic tendinopathy
Activity-related joint stiffness
Reduced functional capacity
Failure of NSAIDs
Refusal or postponement of joint replacement

Risk Factors

Active infection at injection site
Active malignancy
Severe thrombocytopenia
Coagulopathy or anticoagulant therapy
Pregnancy
Severe joint deformity (Kellgren-Lawrence IV)
Recent corticosteroid injection

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Severe pain or swelling after injection
  • Signs of infection
  • Persistent symptoms despite multiple sessions
  • New neurological deficit
  • Allergic reaction
  • Need for surgical evaluation

Treatment Methods

01
Pre-injection assessment with imaging
02
Withhold NSAIDs and anticoagulants per protocol
03
Standardised PRP preparation under sterile conditions
04
Image-guided intra-articular or peritendinous injection
05
Short post-injection rest then progressive rehabilitation
06
Re-assessment at 6, 12 and 24 weeks
07
Combined physiotherapy and weight management

Which Department to Visit?

You can visit our Fizik Tedavi ve Rehabilitasyon department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Fizik Tedavi ve Rehabilitasyon Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.