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Opsoclonus-Myoclonus Syndrome

Rare neurological disorder characterized by chaotic eye movements and muscle spasms.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Opsoclonus-Myoclonus Syndrome?

Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder defined by rapid, irregular, multidirectional eye movements (opsoclonus) together with brief involuntary muscle contractions (myoclonus).

In children it is frequently associated with neuroblastoma, while in adults it may be a paraneoplastic syndrome of lung, breast, or ovarian cancer.

Autoimmune mechanisms are central to its pathogenesis; antineuronal antibodies damage cerebellar and brainstem structures.

Symptoms

Rapid, chaotic, multidirectional eye movements (opsoclonus)
Sudden muscle spasms in the trunk and limbs (myoclonus)
Ataxia with impaired balance and coordination
Irritability and disturbed sleep, especially in children

Risk Factors

Neuroblastoma — the leading cause in children
Lung or breast cancer in adults
Postviral autoimmune triggering

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Detection of unexplained chaotic eye movements
  • Sudden motor regression and irritability in a child
  • Loss of balance with concurrent muscle spasms

Treatment Methods

01
Surgical resection of an underlying tumor
02
Immunotherapy with IVIG, rituximab, or ACTH
03
Corticosteroid therapy
04
Long-term immunosuppression to prevent relapse

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.