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Myasthenic Crisis Management

Acute respiratory failure complication of myasthenia gravis.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Myasthenic Crisis Management?

Myasthenic crisis is an acute exacerbation of myasthenia gravis severe enough to require respiratory support due to weakness of bulbar or respiratory muscles.

It is most often triggered by infection, surgery, certain medications or non-compliance with treatment.

Mortality has decreased significantly with modern intensive care management.

Symptoms

Worsening dyspnea and tachypnea
Inability to clear secretions and swallowing difficulty
Weakness of neck and respiratory muscles
Decrease in vital capacity below 1 liter or 15 ml/kg
Generalized fatigue and ptosis worsening

Risk Factors

Worsening myasthenia gravis or recent diagnosis
Active infection, especially respiratory tract infection
Recent surgery or trauma
Magnesium, fluoroquinolones, beta blockers and aminoglycosides
Discontinuation of immunosuppressive therapy

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Severe respiratory difficulty or aspiration findings — emergency
  • Vital capacity falling below 20 ml/kg
  • Bulbar weakness with risk of choking
  • Severe dysphagia preventing oral intake

Treatment Methods

01
Hospitalization in intensive care and frequent monitoring of vital capacity
02
Endotracheal intubation and mechanical ventilation when necessary
03
Plasmapheresis or IVIG infusion for rapid response
04
High-dose corticosteroids and immunosuppressive therapy
05
Treatment of triggering factor and discontinuation of provoking medications

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.