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Myasthenia Gravis Advanced Treatment

Modern therapy with eculizumab, ravulizumab, efgartigimod and rozanolixizumab.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Myasthenia Gravis Advanced Treatment?

Myasthenia gravis is an autoimmune disease characterized by fluctuating muscle weakness due to development of antibodies against the acetylcholine receptor or MuSK at the neuromuscular junction.

In patients refractory to standard immunotherapy, rapid clinical improvement can be achieved with C5 inhibitors (eculizumab, ravulizumab) and FcRn inhibitors (efgartigimod, rozanolixizumab).

Treatment selection is based on antibody type, side effect profile and cost considerations.

Symptoms

Ptosis
Diplopia
Difficulty speaking
Difficulty swallowing
Proximal muscle weakness
Weakness worsening with fatigue
Respiratory distress

Risk Factors

Thymoma
Female sex (early onset)
Male sex (late onset)
Family history of autoimmunity
HLA subtypes

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Shortness of breath
  • Swallowing problems
  • Sudden ptosis and diplopia
  • Persistent weakness
  • Signs of infection

Treatment Methods

01
Pyridostigmine symptomatic therapy
02
Corticosteroids and azathioprine
03
Thymectomy in selected cases
04
Eculizumab and ravulizumab (C5 inhibition)
05
Efgartigimod and rozanolixizumab (FcRn inhibition)
06
IVIG and plasmapheresis
07
Intensive care support (myasthenic crisis)

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Nöroloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.