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Multiple System Atrophy - Cerebellar Type (MSA-C)

An atypical parkinsonism form with progressive cerebellar ataxia and autonomic failure.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Multiple System Atrophy - Cerebellar Type (MSA-C)?

Multiple system atrophy cerebellar type (MSA-C) is an adult-onset disease characterised by simultaneous degeneration of the cerebellum, pons and autonomic nervous system.

Underlying the disease is alpha-synuclein accumulation in oligodendrocytes; for this reason it is classified as a synucleinopathy.

Onset is usually in the 50s-60s and the disease is rapidly progressive. Cerebellar findings predominate, while parkinsonism is less prominent.

Symptoms

Unsteady, drunken-like gait (ataxic gait)
Dysarthria (slurred speech)
Irregularity of hand and foot movements
Orthostatic hypotension and syncope
Urinary urgency, retention and erectile dysfunction
Snoring and stridor during sleep
REM sleep behaviour disorder

Risk Factors

Advanced age (over 50)
Male sex (slight predominance)
Occupational exposure to organic solvents (suspected)
Rare family history

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Loss of balance developing within a short time
  • Dizziness and fainting on standing
  • Marked slurring of speech
  • Sudden loss of urinary control
  • Interrupted breathing during sleep at night

Treatment Methods

01
Midodrine, fludrocortisone for orthostatic hypotension
02
Symptomatic urinary treatment and catheterisation
03
Physiotherapy and balance training
04
Fall prevention measures and assistive devices
05
CPAP/BiPAP for sleep respiratory support
06
Speech and swallowing therapy
07
Multidisciplinary follow-up
08
Palliative care planning

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.