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Liver Elastography for Fibrosis

Noninvasive staging of chronic liver disease with transient elastography (FibroScan), shear wave elastography, and MR elastography

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Radyoloji department. Book Appointment →

What is Liver Elastography for Fibrosis?

Liver fibrosis stage is the strongest prognostic marker in chronic liver disease and treatment decisions; while liver biopsy is the historic gold standard, sampling error and complication rates have led to the development of noninvasive alternatives. Transient elastography (FibroScan) measures velocity by sending a 50 Hz mechanical pulse into the liver tissue (m/s, kPa); cutoffs depend on the etiology.

Point shear wave elastography (pSWE, ARFI) and 2D shear wave elastography (2D-SWE) are integrated into ultrasound devices; they have higher technical success and provide larger sampling areas. MR elastography (MRE) is the most accurate noninvasive method (AUC 0.92-0.98) and works in obese patients and ascites.

FibroScan failure rates exceed 5-10% in the obese (BMI > 30); the XL probe addresses this. Vibration-controlled transient elastography (VCTE) is rapid and reproducible. Cutoffs vary by etiology: in chronic HCV, F2 ≥ 7.1, F3 ≥ 9.5, F4 ≥ 12.5 kPa.

Symptoms

Persistent transaminase elevation
Chronic hepatitis B/C carrier
Metabolic syndrome and NAFLD suspicion
Alcoholic liver disease
Stigmata of cirrhosis (palmar erythema, spider nevi)
Splenomegaly

Risk Factors

Chronic hepatitis B and C
Heavy alcohol consumption
Obesity and type 2 diabetes
Hyperlipidemia
Drug-related hepatotoxicity
Autoimmune hepatitis

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Persistent transaminase elevation lasting more than 6 months
  • Chronic hepatitis B/C diagnosis
  • Hepatosteatosis on imaging
  • Risk factors (obesity, diabetes)
  • Treatment response follow-up (post-DAA)

Treatment Methods

01
Transient elastography (FibroScan, M/XL probe)
02
2D shear wave elastography (Aplio/EPIQ devices)
03
MR elastography (in obesity and ascites)
04
Liver biopsy (in unclear cases)
05
Annual follow-up (in F0-F2)
06
HCC surveillance (US/AFP every 6 months in F4)

Which Department to Visit?

You can visit our Radyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.