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Lennox-Gastaut Syndrome

A severe childhood epilepsy syndrome with multiple seizure types and cognitive impairment.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Lennox-Gastaut Syndrome?

Lennox-Gastaut syndrome is a severe epileptic encephalopathy that usually starts between ages 3-5, characterized by multiple seizure types, distinctive EEG findings and cognitive impairment.

A significant portion of seizures cause tonic drops and are resistant to treatment; therefore injuries are common.

Underlying causes include structural brain damage, tuberous sclerosis, hypoxia, genetic disorders and transition from West syndrome.

Symptoms

Tonic seizures (especially during sleep)
Atonic seizures and sudden falls
Atypical absence seizures
Myoclonic jerks
Cognitive impairment and behavioral problems
Learning difficulties
Frequent injuries

Risk Factors

Perinatal brain injury
Tuberous sclerosis and other neurocutaneous syndromes
Genetic disorders
Previously experienced West syndrome
Cortical malformations

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Epilepsy with multiple accompanying seizure types
  • Injuries due to sudden drops
  • Coexistence of developmental delay and seizures
  • Diffuse slow spike-wave pattern on EEG
  • Development of treatment resistance

Treatment Methods

01
Valproic acid, lamotrigine, rufinamide
02
Adding clobazam
03
Cannabidiol (CBD) treatment
04
Ketogenic diet applications
05
Vagus nerve stimulator (VNS)
06
Corpus callosum surgery (in resistant drop attacks)

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.