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Lambert-Eaton Myasthenic Syndrome

An autoimmune disease affecting the neuromuscular junction.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Lambert-Eaton Myasthenic Syndrome?

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease of the neuromuscular junction characterized by antibodies against voltage-gated calcium channels at nerve terminals, which reduces acetylcholine release.

About half of cases are associated with malignancy such as small cell lung cancer (paraneoplastic LEMS). The other half occurs as an isolated autoimmune disorder.

Clinically, proximal muscle weakness, brief facilitation with activity, autonomic findings such as dry mouth and constipation, and loss of reflexes are typical. Treatment includes searching for underlying cancer and improving neuromuscular transmission.

Symptoms

Proximal muscle weakness (especially in the legs)
Difficulty climbing stairs and rising from a chair
Brief facilitation after exertion
Dry mouth and metallic taste
Constipation and sexual dysfunction
Loss of deep tendon reflexes
Ptosis and diplopia (less frequent)

Risk Factors

Small cell lung cancer
Other autoimmune diseases
Smoking
Advanced age
Male sex (in paraneoplastic form)
Family history of autoimmune disease
HLA susceptibility

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Concurrent proximal weakness and autonomic symptoms
  • New-onset weakness in a patient with smoking history
  • Failure to respond to myasthenia gravis treatment
  • Accompanying unexplained weight loss and fatigue
  • New neurological symptoms in cancer patients under regular follow-up

Treatment Methods

01
Investigation and treatment of underlying cancer
02
3,4-diaminopyridine
03
Pyridostigmine (limited benefit)
04
Intravenous immunoglobulin and plasmapheresis
05
Immunosuppressive therapies (azathioprine, corticosteroids)
06
Physical therapy and regular follow-up

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.