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CT Brain Perfusion

Mapping of cerebral blood flow and identification of salvageable tissue in acute stroke.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Radyoloji department. Book Appointment →

What is CT Brain Perfusion?

CT perfusion is a functional imaging technique that produces parametric maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) and Tmax by acquiring continuous CT images of the brain during intravenous contrast injection.

In acute ischaemic stroke it distinguishes the infarct core (irreversible damage) from the penumbra (salvageable tissue at risk). Core/penumbra mismatch plays a key role in selecting patients for mechanical thrombectomy.

The DAWN and DEFUSE-3 trials showed that mechanical thrombectomy is beneficial even between 6 and 24 hours in patients selected by perfusion imaging.

Symptoms

Acute ischaemic stroke (large vessel occlusion)
Wake-up stroke (started during sleep)
Stroke with unknown time of onset
Evaluation of transient ischaemic attack (TIA)
Decisions about stroke treatment (thrombectomy candidacy)

Risk Factors

Iodinated contrast allergy
Renal insufficiency
Radiation exposure (additional dose)
Motion artefact (poor cooperation in stroke patients)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Emergency brain CT and CT perfusion are requested together in acute stroke
  • In wake-up stroke or stroke of unknown onset
  • When large vessel occlusion is suspected, for the thrombectomy decision
  • For reperfusion assessment after stroke treatment

Treatment Methods

01
CT perfusion protocol (50–60 mL contrast at 4–5 mL/s)
02
RAPID or similar automated analysis software
03
CBF, CBV, MTT and Tmax maps
04
Calculation of core (Tmax >6 s with CBF <30%) and penumbra volumes
05
Treatment decision based on clinical–radiological correlation

Which Department to Visit?

You can visit our Radyoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.