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Corticobasal Syndrome (CBS)

Atypical neurodegeneration with asymmetric parkinsonism and cortical findings.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Corticobasal Syndrome (CBS)?

Corticobasal syndrome is a progressive neurodegenerative syndrome with combined involvement of the brain cortex and basal ganglia, presenting with levodopa-unresponsive asymmetric parkinsonism and cortical function losses.

It usually starts over age 60; unilateral hand clumsiness, stiffness, and loss of fine motor control are the earliest complaints.

While the underlying pathology is often corticobasal degeneration (tau pathology), progressive supranuclear palsy, Alzheimer pathology, and TDP-43 proteinopathies can also lead to a similar clinical picture.

Symptoms

Unilateral hand clumsiness and stiffness in movements
Asymmetric rigidity and bradykinesia
Apraxia: inability to perform purposeful movements
Alien hand syndrome and uncontrolled limb movements
Focal dystonia and myoclonus
Cortical sensory loss (two-point discrimination, graphesthesia)
Speech disorders and dementia in advanced stages

Risk Factors

Advanced age
Family history of tauopathy group
MAPT gene mutations (rare)
History of neurodegenerative disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Progressive loss of use of one hand
  • Sudden loss of control in hand movements
  • Loss of skills such as buttoning, writing
  • Asymmetric tremor or dystonia
  • Significant impairment in speech

Treatment Methods

01
Symptomatic levodopa trial (usually partial response)
02
Botulinum toxin applications for dystonia
03
Antiepileptics for myoclonus (clonazepam)
04
Occupational therapy and daily life support tools
05
Speech-language therapy
06
Psychosocial support and care planning

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.