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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

A chronic, autoimmune peripheral nerve disease.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)?

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic autoimmune disease that targets the myelin sheath of peripheral nerves. It is regarded as the chronic counterpart of Guillain-Barré syndrome and is distinguished by progression lasting at least 8 weeks.

It usually begins with symmetric weakness, numbness, and loss of reflexes in the arms and legs. Proximal (shoulder, hip) and distal (hand, foot) regions are affected together. The course may be stepwise or in attacks.

With early diagnosis and appropriate immunomodulatory therapy, long-term disability can be prevented. Diagnosis is based on nerve conduction studies, cerebrospinal fluid analysis, and, if necessary, nerve biopsy.

Symptoms

Symmetric weakness in the arms and legs
Long-standing numbness and tingling
Loss of reflexes (especially Achilles and patellar)
Difficulty walking and climbing stairs
Difficulty grasping daily objects
Balance disturbances and falls
Fatigue and loss of energy

Risk Factors

History of autoimmune disease
Diabetes (often coexists with CIDP)
HIV and other chronic infections
Monoclonal gammopathies
Male sex
Age between 40 and 60
Triggers after vaccination or infection (rare)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If weakness progressing for more than 8 weeks is present
  • If loss of reflexes and sensory changes are progressing
  • If serious limitations in walking and daily activities develop
  • If recurrent attacks of weakness occur
  • If worsening occurs in other unexplained neuropathy diagnoses

Treatment Methods

01
Intravenous immunoglobulin (IVIG)
02
Corticosteroids (often initial therapy)
03
Plasmapheresis (plasma exchange)
04
Immunosuppressants such as azathioprine and mycophenolate
05
Physical therapy and rehabilitation
06
Long-term follow-up and dose adjustment

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.