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CADASIL

A hereditary small-vessel disease with recurrent strokes and dementia at a young age.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is CADASIL?

CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary disease affecting small cerebral vessels caused by NOTCH3 gene mutations.

It presents in middle age with migraine attacks with aura, recurrent subcortical strokes, mood disorders, and progressive cognitive decline. A similar history in different family members is striking.

Diagnosis includes characteristic temporal pole white matter findings on MRI, NOTCH3 genetic testing, and electron microscopic findings on skin biopsy.

Symptoms

Migraine with aura at a young age
Recurrent small strokes
Progressive cognitive decline
Depression and mood changes
Gait disturbances
Urinary incontinence
Pseudobulbar features

Risk Factors

Familial inheritance (autosomal dominant)
NOTCH3 mutation
Cardiovascular risk factors (smoking, hypertension)
Equal effect on women and men
History of stroke at a young age
Unexplained white matter lesions
Young adults with migraine

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Unexplained stroke at a young age
  • Similar history in the family
  • Recurrent migraine with neurological deficit
  • White matter lesions detected on MRI
  • Early cognitive decline

Treatment Methods

01
Smoking cessation and risk-factor control
02
Antiplatelet therapy (in selected cases)
03
Migraine prophylaxis
04
Treatment of depression
05
Rehabilitation
06
Family screening and genetic counseling

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.