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Anti-Hu Antibody Paraneoplastic Sensory Neuronopathy

A subacute sensory ganglionopathy associated with anti-Hu antibody.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Anti-Hu Antibody Paraneoplastic Sensory Neuronopathy?

Anti-Hu (ANNA-1) antibody is the target of antibodies against an intracellular RNA-binding protein expressed in central and peripheral neurons. Anti-Hu antibodies are associated with the most classical paraneoplastic neurological syndromes.

Underlying tumor is typically small-cell lung cancer (SCLC, 90%), with a small percentage being neuroblastoma, prostate or breast cancer. Sensory ganglionopathy presents with asymmetric subacute sensory loss, ataxia, dysesthesia and pseudoathetoid movements.

Diagnosis is based on demonstration of anti-Hu antibodies in serum, intensive tumor screening (CT, FDG-PET), nerve conduction study (low-amplitude SNAP, normal CMAP) and skin biopsy. Treatment of the underlying tumor and immunotherapy are administered. Prognosis is poor.

Symptoms

Subacute asymmetric sensory loss
Sensory ataxia and gait disturbance
Severe dysesthesia and pain
Pseudoathetoid movements (hands)
Loss of proprioception
Coexisting limbic encephalitis findings

Risk Factors

Smoking and SCLC
Advanced age (60-75 years)
Male sex (slight predominance)
Other paraneoplastic syndrome history
Underlying neuroblastoma (rare)
Genetic predisposition (HLA)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Subacute progressive sensory loss
  • Sensory ataxia and instability
  • Severe dysesthesia and burning pain
  • Smoker with neurological symptoms
  • Worsening proprioception
  • Pseudoathetoid hand movements

Treatment Methods

01
Treatment of underlying tumor (priority)
02
Anti-Hu antibody screen (serum + CSF)
03
Immunotherapy (IVIG, methylprednisolone)
04
Plasmapheresis and rituximab
05
Symptomatic: gabapentin, pregabalin
06
Rehabilitation and balance training

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.