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Progressive Supranuclear Palsy and Tau Pathology

Atypical parkinsonian syndrome with vertical gaze palsy and postural instability.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Progressive Supranuclear Palsy and Tau Pathology?

Progressive supranuclear palsy PSP is a neurodegenerative disorder caused by abnormal accumulation of 4R-tau protein in the brain.

Findings include progressive vertical supranuclear gaze palsy, postural instability with backward falls, axial rigidity and frontal cognitive symptoms.

Average disease duration is 6 to 9 years and at present there is no curative treatment.

Symptoms

Frequent backward falls in early disease
Vertical gaze palsy especially of downgaze
Axial rigidity rather than limb rigidity
Frontal cognitive impairment, executive dysfunction
Pseudobulbar affect, dysarthria and dysphagia

Risk Factors

Age 60 to 70 years
Family history of tauopathy
MAPT gene mutations in some cases
Slight male predominance

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Frequent unexplained falls in adults older than 60
  • Difficulty looking down or vertical gaze limitation
  • Atypical parkinsonism not responding to dopamine therapy
  • Personality changes and apathy

Treatment Methods

01
Symptomatic treatment: levodopa trial, although response is usually poor
02
Multidisciplinary care: physiotherapy, speech therapy, swallowing rehabilitation
03
Falls prevention and home safety adjustments
04
Trials of tau-targeted disease-modifying treatments are ongoing
05
Palliative care planning at end of life

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.