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Myasthenic Crisis

An emergency in patients with myasthenia gravis requiring mechanical ventilation due to severe weakness of respiratory muscles.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Nöroloji department. Book Appointment →

What is Myasthenic Crisis?

Myasthenic crisis is a potentially life-threatening condition that arises with severe weakness of respiratory muscles in myasthenia gravis and may require mechanical ventilation.

Triggers include infections, surgery, certain medications (aminoglycosides, beta blockers), excessive fatigue, and changes in medication doses. Shortness of breath, swallowing difficulty, and slurred speech may be heralds of crisis.

Early recognition is critical; respiratory function tests (FVC measurement) help predict an approaching crisis. IVIG or plasmapheresis is administered in intensive care.

Symptoms

Increasing shortness of breath
Swallowing difficulty and aspiration risk
Progressive deterioration of speech
Worsening of eyelid drooping and double vision
Marked weakness in neck and extremity muscles
Agitation and high respiratory rate

Risk Factors

Diagnosis of myasthenia gravis
Acute infection
Discontinuation or dose change of anticholinesterase medication
Surgery or anesthesia
Some antibiotics and cardiac medications

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Sudden difficulty breathing in a patient with myasthenia gravis — call 112 immediately
  • If swallowing or speech disturbance is rapidly worsening
  • If neuromuscular symptoms increase along with fever
  • If FVC values are dropping rapidly (during monitoring)

Treatment Methods

01
Intensive care and mechanical ventilation (if necessary)
02
Rapid immune suppression with IVIG or plasmapheresis
03
Discontinuation of triggering medications
04
Antimicrobial treatment if infection is present
05
Long-term immunosuppressive treatment regulation after stabilization

Which Department to Visit?

You can visit our Nöroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.