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Morphea (Localized Scleroderma)

Localized cutaneous fibrosis without systemic involvement

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Morphea (Localized Scleroderma)?

Morphea is a localized form of scleroderma that affects the skin and subcutaneous tissues without involving the internal organs, blood vessels, or nail folds. The disease results from autoimmune-mediated activation of fibroblasts and excessive deposition of type I collagen, leading to dermal sclerosis. Morphea is divided into plaque, generalized, linear, and pansclerotic subtypes.

Plaque morphea is the most common form, characterized by oval ivory-white indurated plaques with a violaceous halo (lilac ring) on the trunk. Linear morphea predominates in childhood and may extend to involve underlying muscle and bone, particularly across joints, posing a risk of contracture.

There is no association with systemic sclerosis (no Raynaud's, no nailfold capillary changes, no organ involvement); ANA may be positive but anti-Scl-70 and anti-centromere antibodies are typically absent.

Symptoms

Oval ivory-white indurated plaque with violaceous (lilac) border
Hyperpigmentation or hypopigmentation
Hair loss and anhidrosis on the lesion
Pruritus or burning sensation in active phase
Joint contracture in linear involvement
Facial asymmetry (en coup de sabre subtype)

Risk Factors

Female sex (3:1)
Age 20-40 (adult) or 5-15 (pediatric)
Trauma or radiation
Borrelia burgdorferi (controversial, regional)
Family history of autoimmune disease
Drugs (bleomycin, taxanes)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • New ivory-colored hardened plaque
  • Plaque with violaceous border (active phase)
  • Joint contracture or limb length discrepancy
  • Linear lesion crossing the midline of the face
  • Lesion progression and increase in number

Treatment Methods

01
Skin biopsy and ANA panel
02
Topical corticosteroids and tacrolimus
03
UVA1 and PUVA phototherapy
04
Oral methotrexate (active and progressive)
05
Pulse intravenous corticosteroid (severe, linear)
06
Mycophenolate mofetil (refractory cases)

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.