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Renal Cell Carcinoma Subtypes

Histological subtypes of kidney cancer.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Üroloji department. Book Appointment →

What is Renal Cell Carcinoma Subtypes?

Renal cell carcinoma (RCC) is the most common form of malignant tumour originating from the renal parenchyma and accounts for approximately 85-90% of all kidney cancers. It has multiple histological subtypes with different biological behaviours.

The most common subtype is clear-cell RCC (75-80%), which is associated with inactivation of the VHL gene. Papillary RCC (10-15%), chromophobe RCC (5%) and collecting-duct carcinoma (<1%) are other important subtypes.

Each subtype has a different prognosis and treatment response. Molecular targeted therapies and immunotherapy have provided significant successes especially in advanced clear-cell RCC. Subtype assignment is performed by the pathologist and is critical in treatment decisions.

Symptoms

Haematuria
Flank pain
Palpable mass
Weight loss
Fever
Paraneoplastic syndromes
Metastatic symptoms

Risk Factors

Smoking
Obesity
Hypertension
VHL syndrome
Tuberous sclerosis
Birt-Hogg-Dubé syndrome
Chronic kidney disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Detection of haematuria
  • Flank pain
  • Incidental mass
  • Weight loss
  • Family history

Treatment Methods

01
Multiphasic CT or MRI
02
Tru-cut biopsy (in selected cases)
03
Partial or radical nephrectomy
04
Targeted therapy (TKI) in metastatic disease
05
Immunotherapy (checkpoint inhibitors)
06
Adjuvant treatment based on subtype
07
Active surveillance for small renal masses
08
Multidisciplinary follow-up

Which Department to Visit?

You can visit our Üroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.