Rathke Cleft Cyst

A benign cystic remnant of Rathke's pouch in the sellar region.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Rathke Cleft Cyst?

A Rathke cleft cyst is a benign cystic lesion that arises from remnants of Rathke's pouch between the anterior and intermediate lobes of the pituitary.

Most cysts are small and asymptomatic.

Larger cysts may cause headaches, hormonal deficiencies or chiasmal compression.

Symptoms

Persistent retro-orbital or frontal headache

Visual field defects when the optic chiasm is compressed

Symptoms of hypopituitarism such as fatigue and amenorrhea

Diabetes insipidus with polyuria and polydipsia

Risk Factors

Adult age of 30 to 60 years

Slight female predominance

Other pituitary or sellar pathology

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Recurrent unexplained headaches
Visual disturbances — urgent
Symptoms suggesting hormonal deficiency or excessive thirst and urination

Treatment Methods

Pituitary MRI and a hormone panel for diagnosis

Periodic monitoring for asymptomatic and small cysts

Transsphenoidal cyst drainage and partial wall excision when there is mass effect or hormonal deficiency

Hormone replacement therapy as needed

Long-term follow-up because of recurrence risk

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Endokrinoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.