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Prurigo Nodularis

A chronic skin disease characterized by intense pruritus and firm, dome-shaped nodules.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Prurigo Nodularis?

Prurigo nodularis is a disease characterized by firm, raised nodules formed by sensitization of cutaneous nerves and chronic scratching. The itch is so severe that patients scratch until they bleed.

It is associated with many conditions such as atopic dermatitis, kidney failure, liver disease, HIV, iron deficiency, and psychiatric disorders. It can sometimes be idiopathic.

In recent years the role of Type 2 inflammation has been recognized; biologic agents such as dupilumab have begun to take their place in treatment.

Symptoms

Symmetric, firm, dome-shaped nodules on the arms and legs
Very severe, sleep-disturbing pruritus
Crusts and excoriation over the lesions
Hyperpigmentation or hypopigmentation
New lesions appear at scratching sites
Marked impairment of quality of life
Secondary bacterial infections

Risk Factors

Atopic dermatitis and history of atopy
Chronic kidney or liver disease
HIV infection
Iron-deficiency anemia and thyroid disorders
A neuropathic or psychogenic pruritus background
Older age
Stress and anxiety

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • When multiple firm nodules form
  • When pruritus interferes with sleep and daily life
  • When pruritus accompanies signs of systemic disease
  • When topical treatment fails to provide a response
  • When infection or bleeding develops in the nodules

Treatment Methods

01
High-potency topical corticosteroids
02
Topical calcineurin inhibitors
03
Intralesional steroid injections
04
Neuromodulators such as gabapentin, pregabalin
05
Phototherapy (narrow-band UVB)
06
Biologic agents such as dupilumab
07
Treatment of the underlying systemic disease

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.