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Porokeratosis

Group of keratinization disorders with annular plaques and a peripheral keratotic ridge.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Porokeratosis?

Porokeratosis is a heterogeneous group of inherited or acquired keratinization disorders defined histologically by a cornoid lamella, a thin column of parakeratotic cells. Clinically, lesions appear as well-demarcated annular plaques with an atrophic center and a raised hyperkeratotic ridge.

The major variants are disseminated superficial actinic porokeratosis (DSAP, the most common, sun-induced), porokeratosis of Mibelli (classic and largest plaques), linear porokeratosis (Blaschkoid), punctate, palmoplantar disseminated and the genetically distinct genodermatosis types.

Lesions can develop into squamous cell carcinoma (3-10% lifetime risk in larger or long-standing variants), so periodic dermatologic surveillance is essential.

Symptoms

Annular plaques with central atrophy
Raised peripheral hyperkeratotic ridge
Multiple lesions on sun-exposed skin in DSAP
Solitary larger plaques in Mibelli variant
Itching or burning
Linear lesions in Blaschkoid distribution
New nodular component suggesting malignant change

Risk Factors

MVK, PMVK, MVD, FDPS gene mutations
Family history of porokeratosis
Chronic sun exposure
Immunosuppression (transplant, HIV)
Phototherapy or PUVA exposure
Fair skin (Fitzpatrick I-II)
Older age (typical onset 30-50 years)

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • New annular hyperkeratotic plaque
  • Sudden growth or thickening of an existing lesion
  • Bleeding, ulceration or nodular component
  • Multiple new lesions on sun-exposed areas
  • Lesion change in a transplant recipient
  • Need for biopsy to rule out squamous cell carcinoma

Treatment Methods

01
Strict daily broad-spectrum sunscreen and photoprotection
02
Topical 5-fluorouracil or imiquimod
03
Topical retinoids (tretinoin, tazarotene)
04
Topical statin/cholesterol compounded therapy in genodermatoses
05
Cryotherapy or curettage for limited lesions
06
Photodynamic therapy
07
Ablative or fractional CO2 laser
08
Surgical excision for malignant transformation

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.