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Pityriasis Rubra Pilaris

Rare disease presenting with orange-red patches and palmoplantar keratoderma.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Pityriasis Rubra Pilaris?

Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease of incompletely understood etiology, characterized by disorders of keratinization.

Five classic clinical types exist; type I (classic adult) is the most common. Orange-red patches starting from the scalp and spreading downward, with islands of sparing, follicular hyperkeratosis, and palmoplantar keratoderma are typical.

Some cases may be confused with psoriasis; spontaneous remission within 1-3 years is seen in a significant proportion of patients.

Symptoms

Orange-red keratotic plaques
Islands of sparing (unaffected normal skin)
Follicular hyperkeratosis
Palmoplantar yellow keratoderma
Generalized scaling and erythroderma
Nail changes
Itching and burning sensation

Risk Factors

Genetic predisposition (family history)
Some infections
Drug-induced flares
HIV infection
Malignancy association (rare)
Trauma
Unknown triggers

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Lesions resembling psoriasis but in orange tone with islands of sparing
  • Thick yellow skin developing on palms and soles
  • Generalized scaling spreading over the body
  • Erythroderma and general deterioration
  • Progression despite treatment

Treatment Methods

01
Topical corticosteroids and keratolytics
02
Oral retinoids (acitretin)
03
Methotrexate
04
Biologic therapies (TNF-alpha inhibitors, IL-17/23 inhibitors)
05
Phototherapy (in selected cases)
06
Moisturizing and emollient care

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.