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Photodynamic Therapy in Dermatology

Light-activated topical therapy for actinic keratosis, superficial skin cancer and selected dermatoses.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Photodynamic Therapy in Dermatology?

Photodynamic therapy in dermatology applies a photosensitizer such as 5-aminolevulinic acid or methyl aminolevulinate to lesional skin, allowing accumulation of protoporphyrin IX in dysplastic and neoplastic cells before activation by visible red or daylight illumination.

It is particularly effective for field cancerization with multiple actinic keratoses, superficial basal cell carcinoma, Bowen disease and certain inflammatory disorders such as acne and refractory warts.

Compared with surgical alternatives, it provides excellent cosmetic outcomes with low scarring but typically requires repeated sessions and adequate sun protection afterwards.

Symptoms

Multiple actinic keratoses on sun-damaged skin
Superficial scaly plaques on the face or scalp
Slow-growing pearly papules of basal cell carcinoma
Persistent erythematous patches of Bowen disease
Refractory acne lesions
Recurrent palmar or plantar warts
Field changes with high cancer risk

Risk Factors

Chronic sun exposure
Fair skin and outdoor occupation
Immunosuppression
History of nonmelanoma skin cancer
Multiple actinic keratoses
Genetic syndromes with skin cancer predisposition
Refractory inflammatory dermatoses

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Severe pain or burning during light exposure
  • Marked swelling and crusting after treatment
  • Persistent ulceration of treated area
  • New or growing lesion within the treated field
  • Suspected infection
  • Severe phototoxic reaction
  • Recurrence after several sessions

Treatment Methods

01
Curettage or gentle preparation of lesional skin
02
Application of photosensitizer with appropriate incubation time
03
Activation by red light, blue light or natural daylight
04
Cooling and analgesia during exposure
05
Strict photoprotection for at least 48 hours
06
Repeat sessions according to lesion type
07
Long-term dermatologic surveillance for new lesions

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.