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PHACE Syndrome

A neurocutaneous syndrome with segmental facial hemangioma associated with brain, cardiac, and ocular anomalies.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is PHACE Syndrome?

PHACE syndrome describes a cluster of structural brain, arterial, cardiac, and ocular anomalies accompanying large segmental infantile facial hemangiomas.

The hemangioma typically grows rapidly in the first weeks, raising diagnostic suspicion. MRI, echocardiography, eye examination, and arterial imaging are planned in the early period.

Propranolol therapy is effective in hemangioma control; in the presence of cerebrovascular involvement, dosing is carefully planned.

Symptoms

Large segmental hemangioma on the face
Intraocular or orbital involvement
Cardiac murmur
Neurological delay
Vision and hearing problems

Risk Factors

Female infant predominance
Prematurity
High birth weight
Twin pregnancy
Segmental hemangioma distribution

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Rapidly growing hemangioma on the face
  • Periocular involvement
  • Cardiac murmur and cyanosis
  • New neurological symptoms

Treatment Methods

01
Propranolol (careful dose titration)
02
Topical timolol in selected cases
03
Multidisciplinary (neurology, cardiology, ophthalmology)
04
Brain and vessel evaluation with MRI/MRA
05
Long-term developmental monitoring
06
Family education

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.