Peters Anomaly
Congenital corneal opacity in anterior segment dysgenesis
This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.
This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Göz Hastalıkları department. Book Appointment →
What is Peters Anomaly?
Peters anomaly is caused by mutations in PAX6, CYP1B1, FOXC1, PITX2, B3GLCT, and other developmental genes affecting neural crest migration during eye development. Type 1 (iridocorneal adhesions) is most common, Type 2 includes lenticulocorneal adhesions or cataract, and Peters Plus syndrome (B3GLCT mutation) features systemic findings (cleft lip/palate, short stature, intellectual disability, cardiac anomalies).
Central corneal opacity blocks early visual development, causing dense deprivation amblyopia if not addressed within the first months of life. The opacity may be partial or complete, unilateral or bilateral. Associated features include shallow anterior chamber, glaucoma (50-70% of cases), microphthalmos, microcornea, sclerocornea, and other anterior segment dysgenesis findings.
Treatment requires urgent evaluation and individualized planning by pediatric ophthalmology with corneal subspecialty input. Optical iridectomy may be considered for paracentral opacities. Pediatric penetrating keratoplasty offers visual rehabilitation in selected cases despite high risk of graft failure. Aggressive amblyopia management with patching and refractive correction is essential. Long-term outcomes depend on opacity severity, surgical timing, glaucoma control, and amblyopia compliance.
Symptoms
Risk Factors
When to See a Doctor?
If you experience any of the following symptoms, seek medical attention promptly:
- Newborn with white corneal opacity
- Reduced or absent red reflex on newborn screening
- Family history of anterior segment dysgenesis
- Cleft lip/palate with eye anomalies
- Buphthalmos or large cornea in infant
- Photophobia, tearing in infant
- Asymmetric eye size
- Suspected glaucoma in infant
- Microphthalmos
- Strabismus or nystagmus in infant
- Suspected congenital cataract
- Failed visual fix-and-follow
- Considering pregnancy with family history (genetic counseling)
- Postnatal evaluation of any structural eye abnormality
Treatment Methods
Which Department to Visit?
You can visit our Göz Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.
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You can make an appointment with our specialists or contact us for your concerns.
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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.