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Pemphigus Foliaceus

Superficial autoimmune blistering disease driven by anti-desmoglein-1 antibodies.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Pemphigus Foliaceus?

Pemphigus foliaceus (PF) is a superficial intraepidermal autoimmune blistering disease caused by IgG autoantibodies against desmoglein-1.

Lesions are usually shallow, crusted erosions in seborrheic distribution (face, scalp, upper chest and back) and lack mucosal involvement, distinguishing it from pemphigus vulgaris.

Endemic forms (Brazilian fogo selvagem, Tunisian PF) are linked to environmental triggers. Diagnosis combines clinical findings, biopsy with subcorneal acantholysis and serology for anti-Dsg1.

Symptoms

Crusted, scaly erosions on the face and upper trunk
Burning rather than pain at the lesions
No oral or genital ulcers
Photosensitivity in many cases
Pruritus and weeping plaques
Erosions worsen with shaving or rubbing

Risk Factors

Endemic foci in Brazil and Tunisia
HLA-DRB1 susceptibility alleles
Drug triggers: penicillamine, captopril, NSAIDs
Sun exposure may flare disease
Coexisting autoimmune disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Persistent crusted erosions over weeks
  • Spreading scalp/face lesions resistant to topical steroids
  • Suspected drug-induced pemphigus
  • Family or community pattern (endemic regions)
  • Disease relapse during steroid taper

Treatment Methods

01
Topical or low-dose oral corticosteroids in localized disease
02
Rituximab in widespread or refractory disease
03
Steroid-sparing agents (azathioprine, mycophenolate)
04
Sun protection
05
Avoidance of triggering drugs when possible
06
Long-term anti-Dsg1 monitoring

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.