The information on this website is not intended for diagnosis or treatment. Please consult your physician for health concerns.

+90 850 321 50 00

Pan-Drug-Resistant Bacteria

PDR organisms — diagnosis, treatment options, and infection control

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Internal Medicine department. Book Appointment →

What is Pan-Drug-Resistant Bacteria?

Pan-drug-resistant (PDR) bacteria are organisms resistant to all available antibiotics in standard testing panels. Common species include carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacterales producing metallo-beta-lactamases such as NDM and VIM.

These organisms cause ventilator-associated pneumonia, bloodstream infection, intra-abdominal infection, and wound infection in critically ill patients. Mortality reaches 40 to 70 percent. Risk factors include prolonged ICU stay, mechanical ventilation, broad-spectrum antibiotic exposure, and indwelling devices.

Treatment uses cefiderocol as a siderophore cephalosporin, polymyxin B/colistin in combination with carbapenem or sulbactam, ceftazidime-avibactam plus aztreonam for MBL producers, and bacteriophage therapy in select cases. Strict contact precautions and antibiotic stewardship are essential.

Symptoms

Persistent fever despite antibiotics
Hemodynamic instability
Worsening pneumonia
Surgical wound deterioration
Bloodstream infection markers

Risk Factors

Prolonged ICU stay
Mechanical ventilation
Recent broad-spectrum antibiotic use
Indwelling catheters
International travel or transfer

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • For new fever after 48 hours of empiric treatment
  • For sepsis with multidrug-resistant culture
  • For rapid clinical deterioration
  • For colonization screening before procedures
  • For travel-related infection from endemic regions

Treatment Methods

01
Cefiderocol
02
Polymyxin combinations
03
Ceftazidime-avibactam plus aztreonam
04
Sulbactam high dose for Acinetobacter
05
Bacteriophage therapy
06
Strict isolation and source control

Which Department to Visit?

You can visit our Enfeksiyon Hastalıkları department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Enfeksiyon Hastalıkları Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

Book AppointmentContact Us

Related Health Topics

Other articles from the same department you may want to explore.

Flu (Influenza)

Enfeksiyon Hastalıkları

Influenza is a seasonal contagious respiratory disease caused by influenza viruses; it presents with high fever, muscle pain, and severe fatigue.

COVID-19

Enfeksiyon Hastalıkları

COVID-19 is a contagious disease caused by the SARS-CoV-2 coronavirus with a wide clinical spectrum ranging from asymptomatic to severe pneumonia.

Upper Respiratory Tract Infection

Enfeksiyon Hastalıkları

Upper respiratory tract infections are diseases that include common cold, pharyngitis, sinusitis, and laryngitis, often of viral origin and self-limited.

Urinary Tract Infection

Enfeksiyon Hastalıkları

Urinary tract infections are common bacterial infections most often caused by Escherichia coli, presenting with burning and frequent urination.

Hepatitis A (HAV)

Enfeksiyon Hastalıkları

Hepatitis A is an acute, self-limited liver infection transmitted via the fecal-oral route causing acute hepatitis without chronicity; supportive care suffices in most cases, while vaccination prevents outbreaks and post-exposure prophylaxis within 2 weeks is effective.

Hepatitis B

Enfeksiyon Hastalıkları

Hepatitis B is a contagious infection caused by HBV virus transmitted via blood, sexual intercourse, and mother-to-child, that can become chronic and progress to cirrhosis and liver cancer.

Hepatitis C

Enfeksiyon Hastalıkları

Hepatitis C is a liver disease caused by HCV virus transmitted mainly by blood; the rate of chronicity is high, but cure is possible with new antiviral drugs.

HIV/AIDS Information

Enfeksiyon Hastalıkları

HIV is a virus that targets the immune system; if untreated, it progresses to AIDS. With modern antiretroviral therapy, HIV-positive individuals can lead healthy, long lives.

Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.