Paget's Bone Disease - Detailed

A focal disease characterized by abnormal bone remodeling.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Paget's Bone Disease - Detailed?

Paget's disease is a focal bone disease seen in 1-2% of the population over 55; the male:female ratio is 3:2 and it is more common in the United Kingdom, Australia, the United States and Western Europe.

It typically progresses through three phases: first, increased osteoclast activity (lytic phase); second, exaggerated osteoblast response (mixed phase); third, slow burnout (sclerotic phase). It most commonly involves the pelvis, spine, skull, femur and tibia.

Classic complications include 'sabre tibia,' enlarged skull, hearing loss, secondary osteoarthritis, pathologic fracture, high-output heart failure and rarely osteosarcoma. Treatment is intravenous bisphosphonate (zoledronate) and pain management.

Symptoms

Bone pain (especially at night)

Bone deformity (sabre tibia, skull enlargement)

Hearing loss (skull involvement)

Headache

Joint pain (secondary osteoarthritis)

Pathologic fracture

Often asymptomatic (incidental finding)

Risk Factors

Age >55

Male sex

Family history

Northern European origin

SQSTM1 gene mutation

Paramyxovirus infection (hypothesis)

Vitamin D deficiency

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Persistent bone pain
Enlarging head circumference
Hearing loss and tinnitus
Bony deformities
Marked elevation of alkaline phosphatase

Treatment Methods

Confirmation with X-ray and bone scintigraphy

Alkaline phosphatase monitoring

Single intravenous zoledronate 5 mg

Calcium and vitamin D supplementation

Pain management (NSAIDs)

Orthopedic surgery (deformity, fracture)

Hearing follow-up

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Endokrinoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

Book Appointment Contact Us

Related Health Topics

Other articles from the same department you may want to explore.

Anaemia

Dahiliye (İç Hastalıkları)

Anaemia is a low haemoglobin level that reduces oxygen delivery, causing fatigue, pallor, and shortness of breath. It is not a disease itself but a sign of many underlying conditions. Most cases are correctable with appropriate diagnosis and treatment.

Iron Deficiency Anaemia

Dahiliye (İç Hastalıkları)

Iron deficiency anaemia develops when dietary intake, absorption, or losses create an iron shortfall, most often affecting women and children. Identifying the underlying cause is the core of management, alongside iron replacement.

Vitamin B12 Deficiency

Dahiliye (İç Hastalıkları)

Vitamin B12 deficiency can cause megaloblastic anaemia, neurological symptoms, and cognitive impairment. Early treatment with intramuscular or oral B12 largely prevents irreversible complications.

Hypertension (High Blood Pressure) Management

Dahiliye (İç Hastalıkları)

Hypertension is often called the silent killer because it progresses symptom-free for years and can damage the heart, brain, kidneys, and eyes. Regular monitoring, lifestyle change, and evidence-based drug therapy dramatically reduce cardiovascular risk.

Chronic Kidney Disease

Dahiliye (İç Hastalıkları)

Chronic kidney disease is one of the most common complications of chronic conditions such as diabetes and hypertension, and can be silent in its early stages.

Hepatitis B (HBV)

Dahiliye (İç Hastalıkları)

Hepatitis B is a DNA virus infection causing acute and chronic hepatitis with risk of cirrhosis and hepatocellular carcinoma; diagnosis integrates HBsAg, HBeAg, anti-HBc, and HBV DNA with management based on disease phase using nucleos(t)ide analogues (entecavir, tenofovir) and universal infant vaccination.

Hepatitis C (HCV)

Dahiliye (İç Hastalıkları)

Hepatitis C is an RNA virus causing chronic hepatitis that may progress to cirrhosis and hepatocellular carcinoma; modern direct-acting antiviral (DAA) pangenotypic regimens (sofosbuvir/velpatasvir, glecaprevir/pibrentasvir) achieve sustained virologic response over 95% in 8–12 weeks with universal adult screening and cure for nearly all patients.

Fatty Liver Disease

Dahiliye (İç Hastalıkları)

Non-alcoholic fatty liver disease (NAFLD) is closely related to obesity and metabolic syndrome and is largely reversible with early treatment.

Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.