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Non-Seminomatous Germ Cell Tumour

An aggressive mixed testicular tumour.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Üroloji department. Book Appointment →

What is Non-Seminomatous Germ Cell Tumour?

Non-seminomatous germ cell tumours (NSGCT) form a heterogeneous group consisting of combinations of embryonal carcinoma, yolk sac tumour, choriocarcinoma and teratoma. They are usually seen in men between 20 and 35 years of age and behave more aggressively than seminoma.

Elevated AFP and beta-hCG are characteristic. The choriocarcinoma component is associated with high hCG, the yolk sac component with high AFP. Diagnosis is made after radical orchiectomy and tumour markers are critically important during follow-up.

Treatment strategy is determined by stage. In stage I, options include active surveillance, nerve-sparing retroperitoneal lymph node dissection (RPLND) or chemotherapy. In advanced stages BEP (bleomycin, etoposide, cisplatin) chemotherapy is used and success rates are high.

Symptoms

Rapidly growing testicular mass
Testicular pain and firmness
Hydrocele
Back pain (retroperitoneal metastasis)
Shortness of breath (pulmonary metastasis)
Haemoptysis
Weight loss

Risk Factors

Undescended testis
Young age
Family history
Contralateral testicular tumour
Infertility
Testicular atrophy
Klinefelter syndrome

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Testicular mass
  • Painless testicular enlargement
  • Back pain plus testicular swelling
  • Shortness of breath
  • Gynaecomastia

Treatment Methods

01
Scrotal ultrasound and tumour markers
02
Radical inguinal orchiectomy
03
Staging with thoraco-abdomino-pelvic CT
04
Stage I: surveillance/RPLND/chemotherapy
05
Stage II-III: BEP chemotherapy
06
Sperm banking (fertility preservation)
07
Postchemotherapy residual mass surgery
08
Long-term tumour marker follow-up

Which Department to Visit?

You can visit our Üroloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Üroloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.