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Necrobiosis Lipoidica

Atrophic granulomatous skin disease occurring in the pretibial region especially in diabetic patients

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Necrobiosis Lipoidica?

Necrobiosis lipoidica (NL) is a chronic granulomatous skin disease that occurs especially on the anterior aspect of the legs (pretibial region), presenting with yellow-brown, shiny, atrophic, and well-demarcated plaques. A significant portion of cases are associated with diabetes mellitus, but it can also be seen in non-diabetic individuals.

Pathogenesis involves microvascular structure inflammation, collagen degeneration, and granulomatous reaction. Lesions grow slowly, telangiectasias become prominent, and over time may ulcerate due to trauma or infection.

NL creates both aesthetic and functional problems. In ulcerated cases, there is risk of pain and secondary infection. Treatment includes topical or systemic approaches according to clinical severity.

Symptoms

Yellow-brown plaques on the anterior aspect of legs
Shiny, atrophic skin over the plaques
Telangiectasias and fine streaks
Slowly growing, well-demarcated lesions
Easy ulceration after trauma
Pain or burning
Accompanying diabetic symptoms

Risk Factors

Diabetes mellitus (especially long-standing)
Thyroid diseases
Female sex
Trauma and mechanical friction
Microvascular dysfunction
Smoking

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • If new yellow-brown plaques develop on your legs
  • If existing lesions ulcerate
  • If discharge or foul odor comes from ulcers
  • If your diabetes control has deteriorated
  • If lesions are growing rapidly or appearing in new areas

Treatment Methods

01
High-potency topical corticosteroids and intralesional triamcinolone
02
Topical tacrolimus and pimecrolimus
03
Pentoxifylline and aspirin (microvascular support)
04
Systemic options such as dapsone, hydroxychloroquine
05
TNF-alpha inhibitor biologics (refractory cases)
06
Special wound care in ulcerated lesions

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.