Myxedema Coma

Severe hypothyroidism decompensation with altered consciousness and hemodynamic compromise.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Myxedema Coma?

Myxedema coma is the decompensated state of long-untreated or uncontrolled severe hypothyroidism, characterized by hypothermia, bradycardia, hypoventilation, hyponatremia and altered consciousness, and is a medical emergency.

It is more common in elderly women during winter. Infection, sedative drugs, surgery and cold exposure may serve as triggers. Co-existing hypocortisolemia requires additional treatment.

Treatment includes intravenous levothyroxine, liothyronine if needed, glucocorticoids, rewarming, ventilatory support and treatment of infection. Mortality is high so early intervention is critical.

Symptoms

Hypothermia and cold skin

Bradycardia and hypotension

Hypoventilation and hypercapnia

Altered consciousness, stupor, coma

Hyponatremia

Periorbital edema and myxedematous skin

Heart failure

Risk Factors

Long-untreated hypothyroidism

Elderly female sex

Winter months

Infection and sepsis

Use of sedatives

Surgery and trauma

Concomitant hypoadrenalism

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Hypothermia plus bradycardia plus altered consciousness
Acute deterioration in chronic hypothyroidism
Hypoventilation and hypercapnia
Hyponatremia plus myxedematous appearance
Elderly patient with infection plus loss of consciousness
History of thyroid surgery plus acute presentation

Treatment Methods

IV levothyroxine loading

Liothyronine if needed

IV glucocorticoid

Hypothermia management (passive rewarming)

Ventilatory support

Treatment of infection

Electrolyte and volume balance

Endocrine and intensive care follow-up

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Endokrinoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.