Multisystem Inflammatory Syndrome in Adults (MIS-A)

Severe post-COVID inflammatory syndrome with multi-organ involvement.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Multisystem Inflammatory Syndrome in Adults (MIS-A)?

Multisystem inflammatory syndrome in adults (MIS-A) is a severe, multi-organ inflammatory disorder that typically appears 2 to 6 weeks after SARS-CoV-2 infection. It is the adult counterpart of MIS-C in children.

Cardiac involvement (myocarditis, coronary dilation), gastrointestinal symptoms, mucocutaneous findings, and neurological features are common. Markedly elevated inflammatory markers — CRP, ferritin, and D-dimer — are characteristic.

Diagnosis is based on prior or active SARS-CoV-2 infection, multi-organ involvement, and elevated inflammation. Management combines intravenous immunoglobulin, corticosteroids, and supportive care.

Symptoms

Prolonged fever lasting 3 days or more

Chest pain and signs of cardiac involvement

Abdominal pain, diarrhea, and vomiting

Skin rash and conjunctivitis

Hypotension and shock

Lymphadenopathy

Neurological symptoms — headache and altered mentation

Risk Factors

Recent COVID-19 infection

Young and middle-aged adults

Male sex

Black or Latinx ancestry per US data

Unvaccinated or incompletely vaccinated status

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Persistent post-COVID fever with multi-organ symptoms
Onset of chest pain or shortness of breath
Severe abdominal pain and dehydration
Hypotension or signs of shock

Treatment Methods

Intravenous immunoglobulin (IVIG)

High-dose corticosteroids

Anti-IL-6 therapy (tocilizumab) in refractory disease

Anticoagulation for thrombosis prophylaxis

Cardiac support and intensive care monitoring

Long-term follow-up of any coronary artery dilation

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.