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MEN1 Syndrome (Detailed Management)

Multiple endocrine syndrome with parathyroid, pituitary and pancreas tumors.

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is MEN1 Syndrome (Detailed Management)?

MEN1 (Multiple Endocrine Neoplasia Type 1, Wermer syndrome) is an autosomal dominant disease caused by MEN1 gene mutations. It is characterized by the triad of primary hyperparathyroidism (95%), pituitary adenoma (30-40%) and gastroenteropancreatic NETs (60%).

Adrenal tumors, carcinoids, meningioma, lipomatosis, angiofibromas and collagenomas may also be seen. It can present with hormonal syndromes such as hypoglycemia (insulinoma), peptic ulcer disease (gastrinoma) and acromegaly.

Management is multidisciplinary and includes annual biochemical screening, periodic imaging, genetic counseling and proactive surgical approaches. Early diagnosis and lifelong monitoring substantially improve prognosis.

Symptoms

Symptoms of hypercalcemia
Peptic ulcer disease (gastrinoma)
Hypoglycemia attacks (insulinoma)
Acromegaly or prolactinoma findings
Kidney stone
Cutaneous angiofibromas
Weight changes

Risk Factors

Family history of MEN1
MEN1 gene mutation
Early-onset endocrine tumor
Multiple endocrine tumors
Parathyroid plus pituitary plus NET
Recurrent hypoglycemia
Refractory ulcer disease

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Multiple endocrine system findings
  • Family history of MEN1
  • Recurrent kidney stones plus pituitary
  • Request for genetic testing
  • Pancreatic NET findings
  • Hypoglycemia plus gastrinoma

Treatment Methods

01
Subtotal parathyroidectomy
02
Pituitary surgery or medical therapy
03
Pancreatic NET resection or somatostatin
04
Genetic counseling
05
Family screening
06
Annual biochemical follow-up
07
MR and DOTATATE PET
08
Endocrine surgery center

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.