Male Osteoporosis (Endocrine)

Bone loss in men driven by endocrine disorders, hypogonadism, and secondary causes.

Written by: Saygı Hospital Health Guide Editorial Board

Published: February 1, 2026

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Endokrinoloji department. Book Appointment →

What is Male Osteoporosis (Endocrine)?

Male osteoporosis is a metabolic bone disease characterized by reduced bone mineral density and increased fracture risk in men. It affects approximately 1 in 5 men over 50 and is significantly underdiagnosed compared to women.

Up to 50-60% of cases are secondary to identifiable causes, particularly endocrine disorders. Hypogonadism (primary, secondary, or androgen deprivation therapy), hyperparathyroidism, hyperthyroidism, glucocorticoid excess and growth hormone deficiency are major endocrine etiologies.

Diagnosis requires DEXA scan with T-score ≤-2.5 or fragility fracture history, alongside thorough endocrine workup. Treatment combines lifestyle measures, calcium-vitamin D, hormone replacement when indicated, and antiresorptive or anabolic agents.

Symptoms

Fragility fractures (vertebra, hip, wrist)

Loss of height

Back pain (often from vertebral fractures)

Kyphosis

Reduced grip strength

Symptoms of hypogonadism (low libido, fatigue)

Symptoms of underlying endocrine disease

Risk Factors

Hypogonadism (primary or secondary)

Long-term glucocorticoid therapy

Hyperparathyroidism

Hyperthyroidism

Androgen deprivation for prostate cancer

Smoking and alcohol abuse

Family history and low body weight

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Fragility fracture in men over 50
Significant height loss
Symptoms of hypogonadism
Long-term steroid use
Endocrine disorder with bone pain
Family history of osteoporosis

Treatment Methods

Bisphosphonates (alendronate, zoledronate)

Denosumab as alternative

Teriparatide for severe cases

Testosterone replacement in hypogonadism

Calcium and vitamin D supplementation

Treat underlying endocrine cause

Lifestyle modification (exercise, smoking cessation)

Which Department to Visit?

You can visit our Endokrinoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Endokrinoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.