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Lymphomatoid Papulosis

Low-grade cutaneous lymphoproliferative disorder with recurrent papulonodular lesions.

Written by: Saygı Hospital Health Guide Editorial Board
Published:

This content is for general information; please consult your physician for diagnosis and treatment.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Lymphomatoid Papulosis?

Lymphomatoid papulosis (LyP) is a chronic skin disease characterized by recurrent papules, nodules, and ulcerative lesions, containing histopathologically atypical CD30-positive T cells.

Although it has a favorable course, a small portion of patients may develop mycosis fungoides, anaplastic large cell lymphoma, or Hodgkin lymphoma over time.

Lesions can resolve spontaneously within a few weeks; however, they continuously recur in new cycles. Therefore, regular dermatologic monitoring is required.

Symptoms

Recurrent red papules and nodules on trunk and extremities
Necrosis and ulcer formation in lesions
Self-healing courses that may leave scars
Mild itching or pain
Lesions in different stages coexisting
Usually no systemic symptoms
Years-long chronic course

Risk Factors

Young to middle-aged adults
Male sex (mild predominance)
Immune system dysregulation
Prior history of cutaneous T-cell lymphoma
Genetic predisposition
Unclear environmental triggers
History of other lymphoma

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Recurrent papules and nodules not healing spontaneously
  • Increase in lesion number and size
  • Detection of lymph node enlargement
  • Systemic symptoms such as fever, weight loss
  • Behavioral change in previously diagnosed LyP

Treatment Methods

01
Topical corticosteroids
02
Narrow-band UVB or PUVA phototherapy
03
Low-dose methotrexate
04
Bexarotene or topical retinoids (selected cases)
05
Brentuximab vedotin (in advanced cases)
06
Regular dermatologic and hematologic follow-up

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dermatoloji Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.