Lymphocytic Colitis

A subtype of microscopic colitis with intraepithelial lymphocyte infiltration.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 10, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dahiliye (İç Hastalıkları) department. Book Appointment →

What is Lymphocytic Colitis?

Lymphocytic colitis is one of the two main types of microscopic colitis; female predominance is less marked than in collagenous colitis (female:male 1.5-3:1) and the mean age is 50-60.

Drugs (NSAIDs, lansoprazole, sertraline, ranitidine), autoimmune diseases, smoking, viral infections, and bile acid malabsorption are implicated; histologically, an increased number of intraepithelial lymphocytes (>20/100 enterocytes) is the hallmark.

Diagnosis is made by colonoscopic random biopsy. Budesonide 9 mg/day produces remission in 80%, but recurrence rate is 50-70%. Smoking cessation, drug review, and lifestyle changes are important.

Symptoms

Chronic non-bloody watery diarrhea

Nocturnal diarrhea (50%)

Cramping abdominal pain

Bloating

Mild weight loss

Fatigue

Fecal urgency

Risk Factors

Age 50-60

Autoimmune diseases (celiac most common)

Drugs (NSAIDs, PPIs, SSRIs)

Smoking (active or former)

Family history

HLA-DQ2 positivity

Mostly female sex

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Watery diarrhea lasting more than 4 weeks
Nighttime diarrhea
Symptoms despite dietary modification
Symptoms causing weight loss
Fluid-electrolyte imbalance

Treatment Methods

Colonoscopic random biopsy

Discontinuation of triggering drugs

Smoking cessation

Budesonide 9 mg/day for 6-8 weeks

Loperamide for symptomatic relief

Bismuth subsalicylate

Long-term low-dose maintenance therapy

Which Department to Visit?

You can visit our Dahiliye (İç Hastalıkları) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About Dahiliye (İç Hastalıkları) Department

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.