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Lipodermatosclerosis

Sclerosing panniculitis associated with chronic venous insufficiency

Written by: Saygı Hospital Health Guide Editorial Board
Last updated:

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

References (5)

This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our Dermatoloji department. Book Appointment →

What is Lipodermatosclerosis?

Lipodermatosclerosis (LDS), also known as sclerosing panniculitis or hypodermitis sclerodermiformis, is a chronic fibrosing panniculitis of the medial lower leg almost universally associated with chronic venous insufficiency. The disease progresses through acute, subacute and chronic phases, ultimately producing the pathognomonic inverted champagne bottle deformity (sclerotic narrowing of the gaiter area).

Pathogenesis involves venous hypertension causing capillary leak, fibrin deposition, leukocyte trapping and chronic inflammation of subcutaneous fat. Risk factors include obesity, history of deep vein thrombosis, varicose veins, prolonged standing and middle-aged or older female sex. Untreated LDS progresses to venous ulceration in 13 to 50% of cases.

Symptoms

Painful red plaque on medial leg in acute phase
Brownish hyperpigmentation
Hardening (induration) of skin over time
Inverted champagne bottle leg shape
Stasis dermatitis with eczema
Edema below the affected area
Decreased skin mobility (woody feel)
Venous ulceration in advanced disease

Risk Factors

Chronic venous insufficiency
History of deep vein thrombosis
Varicose veins
Obesity (BMI > 30)
Female sex aged 40-70
Prolonged standing or sedentary lifestyle
Pregnancy and parity
Smoking

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

  • Persistent red painful area on medial leg
  • Skin tightening and discoloration on the leg
  • Open ulcer on the lower leg
  • Bottle-shaped deformity of the lower leg
  • Varicose veins with skin changes
  • Venous insufficiency symptoms
  • Painful skin hardening on shins

Treatment Methods

01
Venous duplex ultrasound to confirm reflux and obstruction
02
Class 2-3 graduated compression stockings (30-40 mmHg)
03
Multilayer compression bandaging in active disease
04
Pentoxifylline 400 mg three times daily as adjunct
05
Low-dose stanozolol or anabolic steroids for fibrinolysis
06
Endovenous laser ablation or radiofrequency for superficial reflux
07
Skin moisturization and topical corticosteroids for stasis dermatitis
08
Weight loss and leg elevation
09
Venous ulcer wound care with compression

Which Department to Visit?

You can visit our Dermatoloji department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.