Laryngopharyngeal Reflux (LPR)

Backflow of gastric content into the upper aerodigestive tract.

Written by: Saygı Hospital Health Guide Editorial Board

Last updated: June 11, 2026

This content has been compiled by the Saygı Hospital Health Guide Editorial Board and is periodically reviewed by a specialist physician.

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This content is for informational purposes only and does not constitute medical advice. You can book an appointment at our KBB (Kulak Burun Boğaz) department. Book Appointment →

What is Laryngopharyngeal Reflux (LPR)?

Laryngopharyngeal reflux (LPR) is the retrograde flow of gastric contents (acid, pepsin, bile) into the larynx, pharynx and upper airway. Unlike classic GERD, daytime upright reflux predominates and heartburn is often absent. Pepsin activated by acid causes laryngeal mucosal injury and chronic inflammation.

Diagnosis is based on Reflux Symptom Index (RSI), Reflux Finding Score (RFS) on laryngoscopy and response to empiric proton pump inhibitor therapy. 24-hour multichannel intraluminal impedance-pH monitoring is the gold standard for refractory cases.

Symptoms

Chronic throat clearing

Globus sensation (lump in throat)

Hoarseness, especially morning

Chronic dry cough without asthma

Postnasal drip sensation

Excess throat mucus

Dysphagia and odynophagia

Risk Factors

Obesity and increased intra-abdominal pressure

High-fat, spicy, acidic diet

Late-night eating and lying down soon after meals

Alcohol, caffeine and smoking

Hiatal hernia

Pregnancy and hormonal influence on LES tone

Chronic stress and anxiety

When to See a Doctor?

If you experience any of the following symptoms, seek medical attention promptly:

Persistent throat symptoms over 4 weeks
Hoarseness lasting more than 2 weeks
Suspected aspiration or chronic cough
Globus refractory to PPI
Dysphagia, odynophagia or weight loss
Failure of empiric PPI therapy

Treatment Methods

Lifestyle and dietary modification (low-fat, low-acid, no late meals)

Weight reduction in overweight patients

Head-of-bed elevation 15-20 cm

Avoidance of tobacco, alcohol and caffeine

Twice-daily proton pump inhibitor for 8-12 weeks

Alginate suspension for postprandial reflux

H2 receptor antagonist as bedtime add-on

Pepsin inhibitor and lifestyle counseling

Antireflux surgery (Nissen fundoplication) for refractory cases

Which Department to Visit?

You can visit our KBB (Kulak Burun Boğaz) department for these complaints. Our specialist physicians will create the most suitable treatment plan for you.

Learn About KBB (Kulak Burun Boğaz) Department

Let us help you

You can make an appointment with our specialists or contact us for your concerns.

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Health Disclaimer: The information on this page is prepared for general informational purposes only. It does not replace medical diagnosis and treatment. Please consult your physician for your complaints. Saygı Hospital does not accept responsibility for actions taken based on the information on this page.